I-nasopharyngeal (nay-zoh-fuh-RIN-jee-ul) i-carcinoma ngumhlaza ovela kwi-nasopharynx, ehlala emva kwempumlo yakho nangaphezulu komqala wakho.
I-Nasopharyngeal carcinoma inqabile eUnited States.Kwenzeka rhoqo ngakumbi kwezinye iindawo zehlabathi-ngokukodwa kuMzantsi-mpuma Asia.
I-nasopharyngeal carcinoma kunzima ukuyifumanisa kwangoko.Oku mhlawumbi ngenxa yokuba i-nasopharynx ayilula ukuyihlola kwaye iimpawu ze-nasopharyngeal carcinoma zilinganisa ezinye, iimeko eziqhelekileyo.
I-Nasopharyngeal carcinoma ubukhulu becala yenzeka kubantu ababudala buphakathi kunye nabantu abadala abangaphezu kweminyaka engama-40 ubudala, kwaye ineempawu ezicacileyo zengingqi kunye neentsapho, kwaye izinga lezehlo e-Guangdong liqala e-China, ekwabizwa ngokuba yi "Guangdong cancer".
1.Izikhokelo zokuHlola kunye noNyango lwe-Nasopharyngeal carcinoma
Kwizikhokelo ze-2021 ze-Diagnostic kunye noNyango lwe-Nasopharyngeal Carcinoma, i-Chinese Society ye-Clinical Oncology (CSCO) yayiquka iindlela zokufumanisa i-serological kwi-Class I ubungqina bokuxilongwa kwe-nasopharyngeal carcinoma, kwaye yabonisa ukuba ukudibanisa kwe-EB-VCA-IgA. kunye ne-EB-NA1-IgA EB-virus ye-antibodies inokunyusa izinga lokuxilongwa kwangaphambili kwe-nasopharyngeal carcinoma ngamaxesha e-3 (21% ~ 79%) kunye nokunciphisa umngcipheko wokufa ngama-88%!I-2019 Expert Consensus kwi-Clinical Application of Markers ye-Nasopharyngeal Carcinoma iphinde yabonisa ukuba i-EBV-EA-IgA ngumqondiso wentsholongwane ye-EBV yakutshanje okanye ukwanda okusebenzayo kwe-EBV, kunye neqondo eliphezulu lokuchaneka, kwaye lihlala lisetyenziselwa ukuhlolwa komhlaza we-nasopharyngeal. kunye nokuxilongwa kwangoko.
Uphononongo lubonisa ukuba ukuchongwa okuthathu okudityanisiweyo kwe-EBV-VCA-IGA, i-EBV-EA-IGA kunye ne-EB-NA1-IgA igubungela ngokupheleleyo i-EBV gene spectrum, ephucula ngokufanelekileyo ubuntununtunu kunye nokukodwa kokubhaqwa kwe-nasopharyngeal carcinoma, ukunciphisa ukubonwa okuphosiweyo, iqinisekisa ukuchaneka ukubikezelwa kwezifo, kwaye uqikelele ukwenzeka kwesifo iminyaka emi-5-10 kwangaphambili, efanelekile kuvavanyo olukhulu lomhlaza we-nasopharyngeal.
2.I-VCA-IgA + EA-IgA + NA1-IgA eveliswe yiBeijing Beier inokubonelela ngeprotocol yokuxilongwa kwangaphambili kwe-Nasopharyngeal Carcinoma.
I-Magnetism particulate immuno chemistry luminescence method
| Igama lemveliso | Ushunqulelo |
| Ikiti yokufumanisa i-antibody ye-EB VCA-IgA | EB-VCA-IgA |
| Ikiti yokufumanisa i-antibody ye-EB EA-IgA | EB-EA-IgA |
| Ikiti yokufumanisa i-antibody ye-EB NA1-IgA | EB-NA1-IgA |
Indlela kaElisa:
| Igama lemveliso | Ushunqulelo |
| EB intsholongwane VCA-IgA Elisa kit | EB-VCA-IgA |
| EB virus EA-IgA Elisa kit | EB-EA-IgA |
| Intsholongwane ye-EB NA1-IgA Elisa kit | EB-NA1-IgA |
3.Ukwenziwa kweMveliso
Ikhithi yovavanyo yeVCA-IgA eveliswe yiBeijing Beier inokutshintsha ikhithi esemgangathweni ye-EU yokufunyanwa kwangoko kunye nokuhlolwa kwe-nasopharyngeal carcinoma.
I-British Medical Journal (BMJ) (impembelelo factor 16.378) yenye yeejenali ezine eziphambili zehlabathi zonyango.Kwi-2017, iqela lophando lipapashe iphepha kwi-British Medical Journal (BMJ) "Uvavanyo lweekiti ezisixhenxe ze-VCA-IgA ELISA zokuxilongwa kwe-nasopharyngeal carcinoma e-China: ityala lokulawula ityala".
Kulo phepha, izigulane ze-200 ezine-nasopharyngeal carcinoma (NPC) kunye ne-200 isampuli eziqhelekileyo ze-serum yabantu (SYSUCC) ezivela kwiZiko leCancer yeYunivesithi yaseSun Yat-sen zafundwa kwaye zavavanywa, kunye nokusebenza kweekiti ze-EB-VCA-IgA (ELISA) eziveliswe yi-8. abavelisi beempawu kwimarike yasekhaya bathelekiselwa uvavanyo lomsebenzi.Isiphetho kukuba ikiti ye-EBV-VCA-IgA (ELISA) eveliswe yiBeijing Beier inefuthe elifanayo lokuxilonga njenge-EBV-VCA-IgA (ELISA) eveliswe yi-reagent ephuma ngaphandle kwe-Oumeng, kunye ne-EBV-VCA-IgA (ELISA) Ikhithi eveliswe yiBeijing Beier inokuthatha indawo yekhithi ethengwe kumazwe angaphandle ukuze ibonwe kwangoko kunye novavanyo lwe-nasopharyngeal carcinoma.Ulwazi lwabavelisi beempawu abathatha inxaxheba kuvavanyo luboniswe kwiThebhile 1, iziphumo zovavanyo ziboniswa kwiThebhile 2, kwaye iziphumo zovavanyo ziboniswa kwiThebhile 3.
Ukuqukumbela uvavanyo
Iikhithi ezintathu ze-VCA-IgA ze-BB, i-HA kunye ne-KSB- zineziphumo zokuxilonga ezilingana nezo zekhithi eqhelekileyo.
Ixesha lokuposa: Feb-23-2023